An Alternative Macrophage Activation Pathway Regulator, CHIT1, May Provide a Serum and Synovial Fluid Biomarker of Periprosthetic Osteolysis
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چکیده
منابع مشابه
Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis.
Interactions between periprosthetic cells and prosthetic wear debris have been recognized as an important event in the development of osteolysis and aseptic loosening. Although the ability of wear debris to activate pro-inflammatory macrophage signaling has been documented, the full repertoire of macrophage responses to wear particles has not been established. Here, we examined the involvement ...
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Aseptic loosening and osteolysis are considered the main long-term problems of hip arthroplasty. Pathogenesis of periprosthetic osteolysis is multifactorial, and both the biological and mechanical factors seem to play an important role. Bearing surfaces continuously generate excessive amounts of micron and submicron particles provoking an adverse inflammatory response of periprosthetic connecti...
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ژورنال
عنوان ژورنال: HSS Journal ®
سال: 2017
ISSN: 1556-3316,1556-3324
DOI: 10.1007/s11420-017-9598-9